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Class 

Book 

(bpyrigM?. 



CQEffilGHT DEPOSIT 



TREATISE ON 
ORGANOTHERAPY 



Treatise on 

ORGANOTHERAPY 

AND 

PLURIGLANDULAR THERAPY 



By 
CHARLES E. SPRING, M. D. 



% 



1921 

PUBLISHED BY THE AUTHOR 

Chicago, Illinois 






Copyright, 1921, 

BY 

CHARLES E. SPRING, M. D. 



All Rights Reserved 



HAMMOND PRESS 
B. CONKEY COMPANY 

CHICAQO 



JAN -3 1922 

©CU653400 



THE SCIENCE OF THE FUTURE 

PHYSICIANS understand, though imperfectly, 
that all pathological conditions may be effectu- 
ally resisted by the organism itself, which fights 
and defends itself energetically against its enemies. 
This organism we little understand in spite of all 
our microscopes, and the weapons with which it 
guards itself are not well defined or known, but 
they are nevertheless real and effective. Their 
action is evidenced, if we merely recall the innu- 
merable spontaneous cures that are noted in tuber- 
culosis. 

In the human organism we discover the true 
panacea, for, as nature creates our enemies, it also 
creates the opposing substances in order that we 
may maintain our organic equilibrium. 

Our scientific works on therapeutics will un- 
dergo a radical transformation. That of the old 
that is efficacious will remain, and the greater 
needs of the future will be met with the series of 
active glandular elements, or the true regulators 
of health, which modern science is beginning to 
know, although our knowledge is still amidst the 
greatest obscurity and confusion, but it is genuine. 



INTRODUCTION 

THE organs, tissues and secretions of animals 
were extensively employed as remedial agents 
in ancient times and many of them were official in 
the pharmacopeias of the last century. Organo- 
therapy is undoubtedly the oldest form of thera- 
peutics. 

The use of glandular products, as remedies in 
pathological conditions, was recently revived by 
Brown-Sequard in 1889. According to the theory 
promulgated by them, all glands, in addition to their 
ordinary secretions, put forth certain materials of 
unknown chemical composition, which pass into the 
blood and perform their definite functions of some 
kind. We now know this to be a proven fact and 
further that these glands of internal secretion exert 
influence, heretofore unsuspected, over distant 
parts of the organism. 

I call your attention to the effect of the entire 
removal of either the thyroid, parathyroid, pancreas 
or adrenal glands. The effect is at once to produce 
symptoms of characteristic and fatal disorders; but 
if a portion of either of these glands is left, or a 
portion of the gland engrafted, these toxic symp- 
toms do not develop. 

It is evident that these disorders, so produced, 
are of auto-toxic origin, the result of chemical 

9 



10 INTRODUCTION 



poison in the blood, that is either eliminated, de- 
stroyed or neutralized, when the gland or glands 
are intact, performing their proper functions. 

It has been demonstrated that the giving of a 
properly prepared preparation of the dead gland 
or a combination of glands, whichever is required, 
will dispel the toxic phenomena, which fact goes 
to prove that the active principle is a chemical sub- 
stance, existing in the gland itself, and is not due 
to the action of living cells, other than to produce 
these active agents (hormones). The transfusion 
of blood from a healthy to an unhealthy individual 
is only the supplying of a normal stream of blood 
charged, as it were, with its full quota of chemical 
substance (the correct amount of hormones). The 
results obtained, if done sufficiently early, are gen- 
erally flattering, at least for a time, or until the 
normal amount of hormones begin to lessen, pro- 
vided nature is not able to assist the patient to 
react and obtain his normal balance. This is one 
of the demonstrations in favor of the pluriglandular 
theory. 

The initial dose of MANY animal extracts 
should be very small and increased as conditions 
may require. This is done to avoid the possible 
systemic disturbance that has been noted in some 
cases. However, the fact must not be lost sight of 
that the patient must receive sufficient dosage 
and it must be remembered that the giving of these 



INTRODUCTION 11 



products should be over an extended period (for 
months) to obtain the best results. 

With certain exceptions animal products are 
not toxic. The following preparations, however, 
must be used with care. Thyroid product must be 
started with a small dose and its reaction watched. 
The extract of prostate is highly toxic; therefore 
the initial dose must be small and the reaction care- 
fully noted. The extracts of adrenal and pituitary 
glands require judicious dosage, as harm might be 
done by prescribing them in a haphazard manner 
and over a too prolonged period. Care must be 
taken in the giving of extracts of pancreas and 
liver in diabetic cases, as extract of pancreas 
should not be given in diabetes of hepatic origin 
and vice versa. The other glandular extracts can 
be given with comparative safety. 

It has been proven that the endocrine glands 
control metabolism, nutrition, development and 
sympathetic functions. They work physiologically, 
they are our regulators. The common expression 
that a chain is no stronger than its weakest link has 
no more fitting analogy than that we are no 
stronger than our weakest endocrine gland secre- 
tion. 

It will be noted from the brief survey of hor- 
mone-therapy that its uses are many and its appli- 
cation is logical. It is obvious that at the present 
time we are only on the fringe of the possibilities 



12 INTRODUCTION 



of such treatment and that the near future will 
develop great results. However, it must be re- 
membered that organic diseases are not amenable 
to organotherapy in the degree that functional dis- 
orders respond to the treatment, though much will 
be accomplished by the proper application of or- 
ganotherapy. 

In the therapeutic application of glandular ex- 
tracts singly we have those products that are spe- 
cific in action and produce a definite physiological 
effect. 

First. Products that produce an effect which 
is not due to any change in the normal hormone 
production, as is noted in the action on the un- 
striped muscles, by the giving of an extract of the 
posterior lobe of the pituitary. Especially is this 
marked on the uterine muscles. 

Second. Products that effect the normal hor- 
mone production. The extract of a gland, when 
given internally, tends to augment the action of 
the same gland and possibly will restore the gland, 
partially, or in whole, to normal health, as the giv- 
ing of ovarian extracts in ovarian troubles and 
thyroid extract in hypothyroidism. 

Third. Products used without a definite specific 
or scientific basis in which the beneficial results 
have been noted, as the giving of parathyroid in 
paralysis agitans and pituitary in functional ovarian 
troubles. 



INTRODUCTION 13 



Fourth. Products that supply the required hor- 
mones of those glands that have been removed, 
destroyed or do not function, as the supplying of 
thyroid in cases of myxedema. As the time passes 
and a more extensive clinical knowledge is obtained 
of the endocrine glands, their use will become one 
of a more specific application to pathological con- 
ditions. 

Fifth. The pluriglandular therapy has proven 
itself to be worthy of our profound thought and 
investigation, as it will prove one of our greatest 
weapons in combating pathological conditions. 
There never was a uniglandular endocrine disorder 
that could exist for any length of time singly, as, 
at once, it will involve other endocrine glands, 
therefore becoming pluriglandular, and the best 
possible manner to meet these pathological condi- 
tions is to employ a pluriglandular product that is 
therapeutically and synergistically indicated to 
meet the conditions. 

The use of drugs should be employed in con- 
nection with organotherapy, or vice versa. The 
proper body and mental conditions of the patient 
must be looked after, as well as the hygiene and 
dietetics. 

With these introductory remarks, we will pass 
on to the discussion of the endocrine glands and 
from there to the pluriglandular therapeutics. 



Treatise on Organotherapy 



ADRENAL GLANDS 

Source and Parts Used. The adrenal or 
suprarenal glands of various animals are used, 
chiefly those of cattle and sheep. There are three 
preparations, namely, the whole gland, the central 
or medulla and the peripheral or cortex. One part 
of the adrenal powder represents about six parts 
of the fresh gland. There is a synthetic preparation 
made that is identical or closely allied chemically. 

Anatomy and Physiology. The suprarenal 
glands, each weighing from sixty to one hundred 
and twenty grains, are two flattened bodies more 
or less globular in shape, of a yellowish color, 
situated behind the peritoneum and in front of the 
upper part of each kidney. The adrenal glands, 
through their hormones, supply the tonicity of the 
involuntary muscles. Upon adrenal action on the 
cardiac and circulatory system, blood pressure 
greatly depends. Adrenal insufficiency is not an 
uncommon condition and has been shown to be 
stimulated by emotional strains (as worry, pain or 
fear). Infectious or toxic diseases are conditions 
of acute adrenal depletion. This same condition, 

15 



16 TREATISE ON 



no doubt, exists in long standing infections, as 
tuberculosis and malnutrition. The active principle 
secreted is adrenalin. 

Central Portion or Medulla is formed of stout 
connective tissue, with highly vascular cells, em- 
bodied in a venous plexus, and is very closely allied 
to the nervous system. In reality, it is said to be a 
part of it. 

Cortex or Peripheral has quite a different his- 
tological structure and physiological action is quite 
different than the medullary part of these glands, 
as the apparent action of this part of the gland is 
to neutralize poison liberated during muscular 
energy. The adrenal glands control development 
of the gonads. 

Therapeutic Indication — Total Gland. Muscular 
fatigue, atony and run down conditions, cardiac and 
circulatory insufficiency, cold extremities, malnutri- 
tion, asthenia, tuberculosis, cachexia, Addison's dis- 
ease, toxic conditions, bronchial asthma, cholera, 
collapse, shock and vomiting of pregnancy. 

Principal Indications Adrenal Total. Muscular 
atony, low vitality, fatigue, cardiac insufficiency, 
bronchial asthma, vomiting of pregnancy and hypo- 
tension. The giving of this product requires great 
care and is not suitable for prolonged administra- 
tion. NOT to be GIVEN in high blood pressure 
or arterio-sclerosis. 

Therapeutic Indication — Central Portion or 



ORGANOTHERAPY IT 

Medulla. Is limited to local use and used in the 
usual chloride solution of 1 to 1,000, as in local con- 
gestions and hemorrhages, conjunctivitis, coryza, 
hay fever, hemorrhage from nose, iritis, keratitis, 
laryngitis, rhinitis or in cases where a vasocon- 
strictor is required. Internally of benefit in bron- 
chial asthma, shock, heart failure, or in cases where 
vasomotor equilibrium is to be controlled. 

Principal Indications Adrenal Medulla. Gener- 
ally limited to local use in surgery, as a vasocon- 
strictor. Also used locally in coryza, nose bleed, 
hay fever, and local congestions. Used internally 
in asthma, bronchial spasms and severe infectious 
diseases. 

Therapeutic Indication Cortex. This product 
is not often used alone, but has been given to 
hasten osseous development and union of fractures. 
May be used in conditions due to defective ovarian 
or testicular development. 

Principal Indications Adrenal Cortex. Defec- 
tive development of gonads. Assists absorption 
and retention of lime; therefore helpful in growth 
of osseous tissue and union of fractures. Has anti- 
toxic properties. 

Counter-indicated. Diabetes Mellitus, vascu- 
lar diseases with hypertension, aneurysm, high 
blood pressure, pulmonary hemorrhage. 

Synergistics. Animal extracts that exert mus- 
cular tone and increase blood pressure. The 



18 TREATISE ON 



suprarenal capsule, total gland, is frequently com- 
bined with ovary, testicle, thyroid and pituitary. 

Dose. Adrenal total gland, one-half to two 
grains. Tablets of one-half grain. Adrenal medulla 
is given according to the acute or chronic condi- 
tions from one-tenth to two grains and larger 
doses. The 1 to 1,000 chloride solution, two to ten 
minims. Tablets of 1/10 grain. Adrenal cortex, 
two to five grains. Tablets of two grains. These 
preparations are to be given three to four times 
daily. 



APPENDIX 

Source and Parts Used. The mucous mem- 
brane of the appendix of hogs is the part used. 
This part is desiccated and powdered. One part 
of the powdered substance represents about twelve 
parts of the fresh membrane. 

Anatomy and Physiology. The appendix, which 
varies from 4 to 6 inches in length, is attached to 
the cecum and is rudimentary in human beings. It 
is said that this organ produces a substance which 
stimulates peristalsis. 

Therapeutic Indication. Digestive disorders, 
intestinal stasis, constipation. 

Dose. Has been used experimentally and is not 
yet well established. 



ORGANOTHERAPY 19 

BLOOD 

Source and Parts Used. Hemoglobin, which 
represents the largest portion of the colored cor- 
puscles, is obtained from the red blood cells of cat- 
tle, is desiccated and put into powder form. 

Normal Serum. This product is obtained from 
the healthy horse and can be obtained in ampules 
or syringes for immediate use. 

Antithyroid Serum. This serum is taken from 
the horse five or six weeks after the thyroid gland 
has been removed. This product is rarely used. 

Leucocyte Extract. This product is obtained 
by the injection of irritating substances into the 
pleural cavity of the horse or of other animals. The 
exudate is aspirated, the cellular element is separ- 
ated, incubated and is available in ampules. 

Anatomy and Physiology. The blood is the 
fluid medium through which all tissues of the body 
are directly or indirectly nourished and represents 
about one-twelfth to one-fourteenth of the weight 
of the body. It has slightly alkaline reaction. The 
fluid part of the blood is called plasma, a colorless 
fluid, and suspended therein are the white and red 
corpuscles. 

Hemoglobin. This product represents organic 
iron and about 90 per cent of the red blood cor- 
puscles. The red blood corpuscles are the oxygen- 
carrying element of the blood. 



20 TREATISE ON 



Normal Serum. The serum contains forma- 
tions of other products that are required to main- 
tain the normal health balance. Normal serum is 
given in cases of infection and hemorrhagic dis- 
eases. 

Antithyroid Serum. It is presumed that by the 
removal of the thyroid the blood becomes charged 
with elements normally held in check by the secre- 
tions of the thyroid. Therefore the antithyroid 
serum is thought to neutralize the toxic product of 
thyroid activity. 

Leucocyte Extract. This product produces a 
decided artificial immunity in infectious diseases 
and relieves overworked leucocytes, thereby pro- 
tecting the higher cells, so that their function is not 
deranged by excessive toxic conditions. 

Therapeutic Indication. Hemoglobin (organic 
iron) is indicated in anemia, chlorosis, malnutrition, 
pernicious anemia and in cases where a general 
systemic tonic is required. 

Synergistics. Thyroid extract in anemia show- 
ing hypothyroidism. This product may also be 
given in combination with spleen extract. 

Dose. Two to five grains, three times per day, 
at meals. Tablets of two grains. 

Normal Serum. Hemorrhages due to defective 
clotting and used as immune serum in septic condi- 
tions, as found in pneumonia, typhoid fever and 
kindred conditions. 



ORGANOTHERAPY 21 

Administration and Dose. May be applied lo- 
cally or injected by methods provided. 

Antithyroid Serum. Indicated in excessive 
secretion of the thyroid gland, Grave's disease. 

Synergistics. Desiccated pancreas, adrenal, 
pituitary. 

Dose. Five grains of powder, two to three 
times per day, given over an extended period of 
time. 

Leucocyte Extract. Severe infections, sep- 
ticemia, pyemia, cerebro-spinal meningitis. 

Synergistics. Nuclein and hemoglobin may be 
given with this product, where there is marked 
anemia, in cases of prolonged systemic infection. 
This product is given hypodermically. 



BONE 

Source and Parts Used. The long bone of vari- 
ous animals, from which the organic matter has 
been extracted, desiccated and put in powdered 
form, is used. 

Anatomy and Physiology. The mineral salts ob- 
tained from bone are said to be easily assimilated 
and produce influence on nutrition and mineral 
metabolism. 

Therapeutic Indication. Indicated in those cases 
in which there is lack of mineral salts, as in malnu- 



22 TREATISE ON 



trition, rickets, tuberculosis, and other forms of 
metabolic dyscrasia. Indicated mineral salts can 
be used with as much benefit as that of bone. 

Dose. Five to ten grains or more, with meals. 
Tablets of five grains. 



BONE MEDULLA 

Source and Parts Used. The medullary part of 
the long bones of young animals is the part used. 
Available in powder. 

Anatomy and Physiology. The extract of bone 
marrow is stimulating and increases both the white 
and red blood corpuscles. 

Therapeutic Indication. This product is indi- 
cated in anemia, pernicious anemia, malnutrition, 
chlorosis, tuberculosis, albuminuria and in cases 
where there is a necessity for an increase in the 
production of the red and white corpuscles. 

Synergistics. Hemoglobin, spleen substance, 
also indicated with restorative drug medications. 

Dose. Five to ten grains of extract four times 
per day after meals. Tablets of five grains. 



BRAIN AND SPINAL CORD 

Source and Parts Used. The brain, cord and 
nervous tissue from the sheep are the parts used. 



ORGANOTHERAPY 23 

With the fat removed, one part of the desiccated 
substance represents about five of the fresh gland. 

Anatomy and Physiology. There are two di- 
visions of the nervous system, the cerebro-spinal 
and the sympathetic. The former is composed of 
the brain, spinal cord, cranial and spinal nerves. 
The latter consists of a series of ganglia with inter- 
vening bands, forming two cords, one on either 
side of the spinal column. There are three plexuses, 
one in the thorax, one in the abdomen and one in 
the pelvis. There are also many small ganglia 
connected with the sympathetic system, supplying 
the viscera, vessels and all other parts of the body. 
Nerve fibres of communication unite the sympa- 
thetic and cerebro-spinal nerves. Nervous tissue is 
divided into two classes, white and gray. 

Therapeutic Indication. The brain and nerve 
substance contains four elements, chief among 
which are lecithin and cholesterin, as well as other 
stimulating properties that act upon nutrition of 
the nervous system. There is an emulsion made 
from the white substance of the brain of cattle 
(Thromboplastin), that is used locally as a hemo- 
static in hemorrhages from the nose, throat or after 
removal of tonsils or adenoids, gastric ulcers, 
hemorrhages from hemorrhoids and other local 
hemorrhages. Lecithin is rich in assimilable form 
of organic phosphorus and is therefore a prepara- 
tion of reconstructive merit and is useful as a 



24 TREATISE ON 



cerebrospinal tonic in depraved conditions. It is 
indicated in neurasthenia, debility, malnutrition 
and in cases where phosphorus is indicated, mental 
and nervous disorders, functional impotence, prem- 
ature senility, hysteria and epilepsy. 

Principal Indications. Loss of nerve energy, 
malnutrition, mental and nervous disorders, func- 
tional impotence, premature senility, neurasthenia, 
locomotor ataxia, chlorosis and profound anemia. 

Counter-indicated. Hemorrhage arterial. 

Synergistics. Hemoglobin, adrenal, spermin 
and nuclein. 

Dose. The desiccated powder, one to three 
grains, three to four times per day. Lecithin con- 
tains 5 per cent of organic phosphorus and is given 
in doses of from one-half to three grains, three 
times per day. This is one of the most useful forms 
of assimilable phosphorus. Tablets of brain and 
spinal cord, one grain. 



CAROTID GLAND 

The carotid gland has been considered part of 
the nervous system, vascular, and now a portion of 
the adrenal system. All do not agree that this 
gland has an internal secretion. From experiments 
with this gland conclusions are formed for and 
against. Further investigation is necessary to de- 



ORGANOTHERAPY 25 

termine the merits of this gland for use in organo- 
therapy. 

DUODENUM— (Secretin) 

Source and Parts Used. About eighteen or 
twenty inches of the upper portion of the mucous 
membrane of the small intestine of pigs is part 
used. Secretin is extracted by means of hydro- 
chloric acid from the scrapings of this portion of 
the small intestine. One part of the desiccated 
extract represents about twelve parts of the fresh 
scrapings. 

Anatomy and Physiology. This part of the 
small intestine begins at the pyloric end of the 
stomach and is about twelve inches long. About 
two or two and one-half inches from the pyloric 
end of the stomach open the pancreatic and 
hepatic ducts. The duodenum is composed of the 
same coats as the stomach. The mucous mem- 
brane consists of a series of folds and is covered 
with columnar epithelium, containing the villi of 
the intestines and glands. Secretin is described as 
the alimentary hormone and has a stimulative effect 
upon the alimentary glands, increasing the action 
of the digestive fluids and their enzymes. It has 
a decided influence upon peristalsis and stimulates 
flow of bile. 

Therapeutic Indications. Secretin is indicated 



26 TREATISE ON 



in intestinal indigestion, where either the pancreas 
or liver, or both, are at fault, clay colored stools. 
It is indicated in cases where food undergoes putre- 
faction in the intestinal tract, autotoxemia, hepatic 
cirrhosis, jaundice, diarrhea of children and consti- 
pation. This product has also been recommended 
in diabetes, but only for its effect on digestion. It 
should be a very useful product in acute and chronic 
conditions, where digestion and nutrition might be 
involved. Secretin may be called the key which 
unlocks the alimentary glands. 

Counter-indicated. Ulcer of the small intes- 
tine and inflammation of the pancreas and liver. 

Synergistics. Pancreatin, papain and other 
products influencing digestion. 

Dose. Secretin, two to four grains given while 
or after eating. Duodenum extract tablets of two 
grains. 

KIDNEYS— ( Nephritin) 

Source and Parts Used. Glomerular substance 
of the kidneys of hogs, sheep and cattle is used. 
One part of the dried powder equals about eight 
parts of the fresh gland (Nephritin). 

Anatomy and Physiology. The kidneys, two 
in number, are situated on either side of the verte- 
bral column. They reach from the twelfth dorsal 
to the third lumbar vertebra, the right kidney being 



ORGANOTHERAPY 27 

a little lower than the left. Each weighs from four 
to six ounces. The kidneys, consisting of the cor- 
tical substance, the medullary and the pelvis, are 
enveloped in a strong capsule. They exert a specific 
and neutralizing effect in toxemia and have an in- 
fluence upon irritating substances of the blood that 
effect the secreting part of the kidneys. They are 
also diuretic. 

Therapeutic Indication. Extract of the kidneys 
is indicated in renal insufficiency, uremia, albu- 
minuria (Bright's disease) and in cases of ascites 
and dropsy that are caused by renal insufficiency 
and lack of nitrogenous metabolism. This product, 
in combination with remedial agents, where dropsy 
or ascites may be due to heart or liver lesion, will 
be found of much service. It has also been known 
to increase elimination of urea. 

Synergistics. Desiccated liver and pancreas 
substance. This product is also used with other 
animal extracts. 

Dose. Nephritin, three grains of desiccated 
kidney substance, three times per day after meals. 
To be increased as conditions demand. Tablets of 
three grains. 

LIVER AND BILE 

Source and Parts Used. The parenchyma of 
the liver of cattle and hogs is used. One part of 



28 TREATISE ON 



the desiccated liver substance represents about six 
parts of the fresh gland. 

Anatomy and Physiology. The liver, the largest 
gland in the body, weighing about four pounds, 
occupies the right hypochondrium region. It is 
composed of lobules from one-tenth to one-twen- 
tieth of an inch in diameter, bound together by loose 
areolar tissue. Each lobule consists of nucleated 
hepatic cells, which form the secreting part of the 
liver. The amount of bile secreted by the hepatic 
cells is influenced by the amount of its blood sup- 
ply. The secretion is increased during digestion 
and retarded between meals. During digestion the 
bile is secreted and carried by the main hepatic duct 
directly into the duodenum and after digestion is 
completed, the bile regurgitates from the common 
bile duct, through the cystic duct, into the gall 
bladder, where it accumulates for the next digestive 
period. The hepatic cells are concerned in the regu- 
lation of the sugar contents of the blood. 

Therapeutic Indication. Desiccated liver sub- 
stance has been used with success in the treatment 
of functional hepatic disorders, as well as conditions 
of an organic nature, as atrophy, cirrhosis and alco- 
holic derangement. 

It is also used in the treatment of diabetes that 
is attributed to disturbance of the liver function. 
This form of diabetes is not as prevalent as pan- 
creatic diabetes. Desiccated liver substance given 



ORGANOTHERAPY 29 

in diabetes of a pancreatic origin aggravates the 
difficulty. Liver substance has been found of value 
in the treatment of rheumatism and gout and is 
also known as an anti-hemorrhagic. 

Counter-indicated. Pancreatic diabetes. 

Synergistics. Spleen substance, bile salts and 
possibly thyroid extract. 

Dose. Five to fifteen grains, three to four times 
per day. Increased as desired. Tablets of five 
grains. 

Therapeutic Indication — Bile. Bile is the most 
efficient cholagogue. In intestinal digestion it as- 
sists in emulsifying the fats of the food and renders 
it capable of lacteal absorption. It lubricates the 
mucous membrane of the intestinal tract, is an anti- 
septic, prevents the decomposition of food through 
the intestines and acts as a natural purgative by 
stimulating the muscular and mucous coats of the 
intestinal tract. Bile salts are indicated in hepatic 
insufficiency, indigestion, constipation and forma- 
tion of gas in the intestinal tract, due to biliary 
insufficiency, and in cases where there is a lack of 
digestion of the fats, as found in children. Dehy- 
drated bile represents about forty parts of the fresh 
fluid. 

Counter-indicated. Obstructive jaundice and 
pancreatic diabetes. 

Synergistics. Hepatic substance. Also pancre- 
atin is very often used with this product. 



30 TREATISE ON 



Dose. Two to five grains of the desiccated 
product, to be increased as indicated. Tablets of 
two grains. 



LUNGS 



Source and Parts Used. Lung tissues from ani- 
mals, preferably lambs, is used. Is desiccated and 
powdered. 

Anatomy and Physiology. The lungs are the 
two organs of respiration, occupying the major por- 
tion of the thoracic cavity, weighing, the right 
twenty-two ounces and the left twenty ounces. The 
right has three lobes and the left two. They are of 
a spongy, elastic texture. The pulmonary par- 
enchyma is formed of lobules composed of a ter- 
minal bronchial tube, air cells, blood vessels, nerves 
and lymphatics, with a small amount of areolar 
tissue. The small air cells measure one-hundredth 
of an inch in diameter. 

Therapeutic Indication. The active principle 
of the lung extract exerts a tonic action upon the 
respiratory tract, especially on the mucous mem- 
brane of the bronchi and pulmonary alveoli. Lung 
extract has been recommended in chronic diseases 
of the lung and pleura, especially those of a puru- 
lent character, and has been used with benefit in 
cases of chronic bronchitis, diseases of the pul- 
monary tissue, purulent pleurisy, pulmonary tuber- 



ORGANOTHERAPY 31 

culosis, pulmonary abscess and emphysema, and is 
said to be of benefit in cases of pulmonary hemor- 
rhages. 

Dose. Five to twenty grains, four to five times 
daily for an extended period. Tablets of five grains. 



LYMPHATIC GLANDS 

Source and Parts Used. Lymphatics of cattle 
are parts used. One part of the desiccated sub- 
stance represents about five parts of the fresh gland. 
This product is very hygroscopic. 

Anatomy and Physiology. The lymphatics are 
transparent vessels, having the same three coats as 
the arteries and veins and are to be found every- 
where in the body with the exception of the nails, 
cuticle, hair and cartilage. They are supplied with 
numerous valves, which give them a beadlike ap- 
pearance. Lymphatics of the mesentery and small 
intestine carry the chyle during digestion and the 
lymph at other times. The lymphatic glands are 
small, solid, round or oval bodies situated along the 
absorbent vessels. The glands break up into sev- 
eral afferent vessels and form plexuses within and 
emerge efferent vessels, which soon unite in a single 
trunk. The lymphoid tissue is filled with lymph- 
cells. These glands are to be found in the mesen- 
tery and along great vessels in the axilla, neck and 



32 TREATISE ON 



groins through which the lymph passes in its 
course, before being discharged into the blood ves- 
sels. It might be said that they act as filters. 
Materials of food not taken directly into the blood 
vessels of the alimentary canal are received by the 
lymphatic absorbents, taken and emptied into the 
lymphatic duct. The lymphatic duct is about 
eighteen inches long and empties into the junction 
of the left internal jugular and subclavian veins, 
where the lymph and chyle are carried and injected 
into the circulation. The right lymphatic duct is 
very small and empties into the junction of the 
right internal jugular and subclavian veins. 

Therapeutic Indication. This product has been 
found of benefit in cases of poorly nourished chil- 
dren, enlarged glands, adenoids and cases that are 
subject to hemorrhages. Also recommended for 
individuals where reconstructive treatment is re- 
quired and might be found of benefit in tubercular 
conditions. 

Synergistics. Thyroid, spleen, spermin and 
orchic substance, calcium salts and drug medication 
as indicated. 

Dose. One-half to one grain of desiccated 
glandular substance, three times per day, to be 
increased as required. Tablets of one-half grain. 



ORGANOTHERAPY 33 

MAMMARY GLANDS 

Source and Parts Used. The parenchymatous 
portion of the mammary gland of udders of goats, 
ewes and cows is part used. One part of desic- 
cated gland represents about four to five parts of 
fresh parenchyma. 

Anatomy and Physiology. The mammary gland, 
which varies in size and weight, is composed of 
lobes, which are subdivided into lobules, bound to- 
gether with connective tissues. The lobules form 
a number of rounded vesicles in groups into which 
their ducts open and by their union form about 
fifteen or twenty excretory ducts. Internal secre- 
tion of the mammary gland antagonizes that of 
corpus luteum, and as a result inhibits activity of 
the ovaries. The active principle stimulates the 
mammary activity and development. It reduces 
congestion of the uterus and favors uterine involu- 
tion after childbirth. 

Therapeutic Indication. Found of benefit in 
uterine hemorrhages due to cancer, fibroids, menor- 
rhagia and metrorrhagia, metritis and endometritis. 
This product is said to be of benefit also in deficient 
lactation and given with the view of overcoming 
complications of the menopause. 

Counter-indicated. Where there is deficient 
ovarian activity and amenorrhea. 

Synergistics. Total pituitary, placental extract 



34 TREATISE ON 



and products which exert similar galactogenic ac- 
tion. Possibly thymus extract could be used with 
benefit. Mammary extract has been known to pro- 
duce slight gastric irritability. In this case it should 
be discontinued for the time being. 

Dose. Two to ten grains, two to three times 
per day, after meals. Tablets of two grains. 



MELANINE 



There exists a coloring matter known as mel- 
anine, that is found in all colored tissues of the body, 
and also forms the principal coloring matter of the 
hair. Melanine appears to contain most of the iron 
derived from destructive assimilation of the blood 
globules. When this product is isolated, it is found 
to be of a dark blackish-brown color and may pro- 
duce all the varying grades of hue to nearly abso- 
lute black. This product is deposited in the 
substance of the cells in the form of minute 
granules. Further research may develop some- 
thing along these lines. 



OVARIES 



Source and Parts Used. The whole ovary from 
cows and sows is used. One part of the ovary, 



ORGANOTHERAPY 35 

desiccated (powdered), represents about six and 
one-half of the fresh ovary. The corpus luteum 
for a time practically supplanted the extract of the 
ovary. One part of the desiccated corpus luteum 
represented about five parts of the fresh gland. 

Anatomy and Physiology. The ovaries, which 
weigh from sixty to one hundred and twenty 
grains, are two flattened oval bodies situated in the 
cavity of the pelvis, one on each side, and are ad- 
herent to the posterior surface of the broad liga- 
ment by their anterior border. They are composed 
of fibrous stroma and connective tissue in which 
are embedded Graafian follicles. The corpus 
luteum, an irregular spot in the ovary, is the site 
of a ruptured Graafian follicle. Both the ovaries 
and the corpus luteum produce very active internal 
hormones or secretions which, no doubt, have to 
do with the control of menstruation and pregnancy. 
They regulate both metabolism and oxidation pro- 
cesses of the body and their administration stimu- 
lates the secretory activity of the ovaries. 

Therapeutic Indication. The removal of the 
ovaries will arrest development, but the transplant- 
ing of the ovarian tissue, under the skin, at once 
remedies these defects, showing that the hormone 
is chemical and not reflex in its action. If the 
ovaries are destroyed by disease or otherwise, ad- 
ministration of the ovarian extract overcomes the 
nervous mental and circulatory disturbances, with 



36 TREATISE ON 



which every physician is familiar. Ovarian extract 
will be found of much therapeutic efficiency when 
administered in functional and organic ovarian dis- 
turbances, such as amenorrhea, dysmenorrhea, neu- 
rosis and reflex conditions, as dizziness, insomnia, 
palpitation, intermittent pulse and mental condi- 
tions associated with these troubles. The relation 
between the ovarian secretion and osteomalacia has 
been subject to much speculation, but it is likely 
that the ovaries more than any other endocrine 
gland, as the thyroid and thymus, are the most con- 
cerned in the production of the disease. The men- 
tal disturbance at the climacteric is relieved by 
ovarian extract. 

Counter-indicated. Pregnancy, cases of hyper- 
secretion of the ovary, extreme pelvic congestion. 

Synergistics. Thyroid extract can be given with 
ovarian extract, but not where there is hyperthy- 
roidism. Total pituitary gland is used. 

Dose. Two to four grains, three times per day, 
between meals, to be increased as indicated. This 
treatment should be given over an extended period 
in order to obtain necessary results. Tablets of two 
grains. 

Corpus Luteum. The therapeutic possibilities 
of ovarian extract are numerous. There exists an 
intimate relation between the thyroid and pituitary 
glands and the ovaries. Ovarian extract is fre- 
quently indicated in disorders of the pituitary, more 



ORGANOTHERAPY 37 

especially when the symptoms point to excessive 
osseous growth in imperfect development. Nearly 
all these patients are inclined to take on flesh, 
whether the deficiency arises in the pituitary, thy- 
roid or ovaries. If there be thyroid insufficiency, 
the patient will have a harsh and rough skin and 
the blood pressure will usually be normal (125 mm. 
Hg.) or a little above. If there be pituitary insuf- 
ficiency, the skin will be soft and smooth and the 
blood pressure will be considerably below normal. 

The secretions of the ovaries are not confined 
entirely to the corpus luteum. We do know, how- 
ever, that corpus luteum is intimately associated 
with nutrition, menstruation, ovulation and lacta- 
tion. The female, during the child-bearing period, 
under normal health, is constantly absorbing corpus 
luteum and, as soon as the corpus luteum of one 
menstrual period has been absorbed, another ap- 
pears to take its place during the next period. 
During the first ten to twelve weeks of pregnancy 
corpus luteum ceases to be absorbed, though it in- 
creases much in size and from this time on is 
gradually taken up by the body. If you note, the 
nausea of pregnancy begins during this period and 
disappears as absorption begins to take place. It 
is evident that the nausea of pregnancy may depend 
much upon this condition. 

Corpus luteum extract has remedial action only 
in the female and acts more efficiently during the 



38 TREATISE ON 



child-bearing period or during this period of absorp- 
tion. The giving of corpus luteum causes a reten- 
tion of nitrogen, a tendency toward the obese and 
a development of the mammary glands. Corpus 
luteum is also a marked vasodilator. The giving of 
an extract of the ovary, where all the Graafian 
follicles have been removed, has quite an opposite 
therapeutic action to that of corpus luteum. Cor- 
pora Lutea are not found in the fetus, girls before 
puberty or women who have ceased to menstruate. 
It is therefore evident that corpus luteum is a true 
puberty body. 

The chemical or active principle of corpus 
luteum has not been determined. 

Counterindicated. Low blood pressure and 
frequent menstruation. 

Synergistics. Thyroid and pituitary. 

Therapeutic Indication. Functional amenor- 
rhea of girls and young women, dysmenorrhea, 
abrupt menopause, neurasthenia associated with 
menstrual disorders and irregular menstruation ac- 
companied with overweight. For relief of per- 
sistent headaches at cyclic periods, this is to be 
given several days before the menstruation. 

Dose. One-half to three grains four times a 
day. 



ORGANOTHERAPY _39 

PANCREAS 

Source and Parts Used. The pancreatic gland 
is obtained from cattle and hogs. The desiccated 
acinus portion is used. One part of the desiccated 
gland represents about five parts of the fresh. This 
preparation is hygroscopic. 

Anatomy and Physiology. The pancreas, a com- 
pound racemose gland, is pyramidal in shape, about 
six inches long, one-half inch wide and one inch 
thick and weighs from two to four ounces. It lies 
behind the stomach and in front of the first lumbar 
vertebra. Its chief function is facilitating the metab- 
olism of carbohydrates. At the splenic or tail end 
of the gland are found from 80 to 90 per cent of 
the islands of Langerhan. Pancreatin, a combi- 
nation of enzymes and well known digestive fer- 
ments, acts only in an alkaline medium. The pan- 
creas produces three well known digestive ferments, 
trypsin, steapsin and amylopsin. These ferments 
take part in the digestion of proteids, fats and car- 
bohydrates. Pancreatic digestion takes place in 
the small intestines. It is quite well established 
that the internal secretion of the pancreas facili- 
tates the burning of the sugar in the muscles and 
reduces blood pressure. The removal of the whole 
pancreas is followed in a short time by fatal dia- 
betes, whereas if pancreatic substance is grafted 
into the animal, glycosuria is prevented. The dia- 



40 TREATISE ON 



betic possesses little phagocytic resistance, is sub- 
ject to infection and is a bad subject for operation. 
He has also little power of resisting tubercle bacil- 
lus. 

Therapeutic Indication. The use of pancreatin 
in intestinal indigestion and for peptonizing milk 
has been well established. One of the principal 
uses of the pancreas substance is to antagonize 
hyperfunction of the adrenal gland in high blood 
pressure and is of benefit in infection of the adrenal 
gland by bacterial and other toxic conditions. It 
is also indicated in pancreatic diseases, where there 
is a lack of the functioning of the gland. Owing 
to its sedative action, it would perhaps be found 
of benefit in Grave's disease. Trypsin has been 
used as a diphtheritic solvent. Pancreas may be 
found of benefit in diabetes mellitus of pancreatic 
origin. It is useful in lowered vitality to prevent 
infections and is recommended in tuberculosis. The 
dropping of a solution of adrenalin in the eye of an 
animal from which the pancreas has been removed 
causes dilatation of the pupil, which action does not 
occur in a normal animal. This test is used at times 
to diagnose pancreatic diabetes from liver diabetes. 

Counter-indicated. In diabetes of hepatic origin. 

Synergistics. Digestive ferments, papain, small 
doses of thyroid in hypertension, adrenal substance 
and posterior pituitary. 

Dose. Two to eight grains, three to four 
times per day. Tablets of two grains. 



ORGANOTHERAPY 41 

PARATHYROID GLANDS 

Source and Parts Used. The parathyroid glands 
are obtained from cattle and horses. The glands 
are desiccated and powdered. One part of the 
powdered substance represents six parts of the 
fresh gland. 

Anatomy and Physiology. These glands are 
situated in the throat and are four in number, two 
pairs, situated in close proximity to the lateral 
lobes of the thyroid gland. The structure bears 
some resemblance to the thyroid gland. The 
glands are formed of columns of granular epithe- 
lium cells and show very vascular connective tis- 
sue between them. Upon the removal of the 
thyroid gland, these glands undergo marked hyper- 
trophy. Parathyroid glands control the destruction 
of toxic substance and are intimately concerned in 
the maintaining of calcium metabolism, therefore 
having a special effect on the nervous system. The 
total removal of these glands is followed by tetany 
and a serious loss of calcium salts, rapidly causing 
death. 

Therapeutic Indication. With the loss of para- 
thyroid secretion there is a marked nervous irrita- 
bility, bordering on tetany. Therefore the ad- 
ministration of this product in nervous, irritable 
conditions is received with favor. This product 
has also proven of benefit in the controlling of con- 



42 TREATISE ON 



vulsions, paralysis agitans and has been found of 
benefit in the treatment of chorea, epileptic convul- 
sions and exophthalmic goiter. 

Synergistics. Bile salts, testicular, ovary and 
hepatic substance. Also to be considered are the 
brain, spinal cord and calcium salts. 

Dose. 1/20 to 1/10 grain two to three times a 
day between meals. Tablets of 1/20 grain. 



PINEAL GLAND 

Source and Parts Used. The pineal body is ob- 
tained from young cattle. The total gland is used. 
This gland is exceedingly small, requiring approx- 
imately five thousand to make one pound of the 
extract. The gland is desiccated and triturated. 

Anatomy and Physiology. The pineal gland is 
a small, reddish body situated beneath and back of 
the corpus callosum and rests on the corpora quad- 
rigemina. The central substance consists of. white 
and gray matter. The blood vessels are small and 
form a delicate capillary plexus. The function of 
this gland has not been well established and is 
really in the experimental stage. The gland is 
known, however, to have a definite physiological 
action in youth. Disordered function in this gland 
produces a marked change in metabolism and ma- 
turity. 



ORGANOTHERAPY 43 

Therapeutic Indication. This gland has been 
used clinically in the treatment of mentally deficient 
children and in cases where there is evidence of 
defective mentality. In early life this gland seems 
to have an influence over nutrition and develop- 
ment of the genital organs. It seems, also, to have 
some effect on the development of the nervous sys- 
tem. Extract of this gland may act favorably in 
chronic functional brain diseases, lack of cerebral 
nutrition, chronic softening, mania and dementia. 

Counter-indicated. This product is apparently 
non-toxic and seems to be of little use when given 
to children over twelve years of age. 

Dose. 1/10 grain, three times a day, between 
meals. To be persisted in for some five or six 
months. Tablets of 1/10 grain. 



PITUITARY BODY 

Source and Parts Used. This gland is obtained 
from cattle. The parts used are the whole gland, 
posterior lobe and anterior lobe. One part of the 
whole gland and the posterior lobe each represents 
about four and one-half parts of the fresh sub- 
stance. One part of the anterior represents about 
five parts of the fresh gland. 

Anatomy and Physiology. The pituitary body, 
consisting of two lobes and weighing from five to 



44 TREATISE ON 



ten grains, is a small, reddish-gray body, occupying 
the Stella turcica of the sphenoid bone. The 
smaller or posterior lobe consists of nervous tissue, 
and the anterior lobe, the larger of the two, resem- 
bles the structure of the thyroid. The vesicles are 
enclosed by a connective tissue rich in capillaries. 
These two distinct parts apparently have separate 
actions, as the posterior lobe can be removed with- 
out much effect, while the opposite is true of the 
anterior. The posterior lobe contains an extremely 
active substance, which stimulates the un-striped 
muscular fibers. This is very marked on the preg- 
nant uterus. It also stimulates mammary activity 
and renal secretion and favors carbohydrate 
metabolism. 

Therapeutic Indication — Posterior Lobe. This 
product is given to hasten labor after the second 
stage has commenced. The using of this product 
in these cases should be done with great care, as 
much damage might result, if precaution is not 
taken. Owing to its action on the heart muscle, it 
might be useful in shock, cardiac weakness and 
heart failure. It also increases blood pressure, 
when given for some time. It is a marked diuretic 
and has been used in uremia and dropsy, although 
great care should be exercised in giving this prod- 
uct in uremia. Owing to the action of this product 
on the intestinal tract, it is found useful in meteor- 
ism, especially following laparotomy. It is useful 



ORGANOTHERAPY 45 

in acute intestinal stoppage and is also important in 
hyperthyroidism, where it is necessary to support 
the heart. This product is useful in uterine involu- 
tion and controlling hemorrhages. It has been used 
with success in threatened mammary abscess and 
in bronchial asthma when used in conjunction with 
adrenalin. Enuresis of children has been benefited 
by this product. 

Principal Indications Pituitary Posterior. Gen- 
eral stimulant upon the un-striped muscular fibres, 
especially marked on the pregnant uterus and is 
USED with CARE in the second stage of labor. 

Counter-indicated. This product should never 
be given in early stage of labor, as its action might 
cause rupture of the uterus. Neither should it be 
used in hypertension or in severe acute nephritis. 

Synergistics. Adrenalin. 

Dose. One-quarter to one grain, three to four 
times per day. Tablets of one-quarter grain. 



PITUITARY BODY ANTERIOR LOBE 

Therapeutic Indication. Delayed mental de- 
velopment in children, amenorrhea of girls and 
young women, asexual individuals, infantilism and 
bronchial asthma. 

Principal Indications Pituitary Anterior. In- 
fantilism, delayed mental development in children, 
amenorrhea, especially in the obese. 



46 TREATISE ON 



Synergistics. Thyroid gonads. 
Dose. One to four grains, three to four times 
per day, between meals. Tablets of one grain. 



PITUITARY BODY WHOLE GLAND 

Therapeutic Indication. To control definite 
symptoms of pituitary diseases, neuralgic pain, 
lethargy and infantilism. It is said to be of some 
benefit in Addison's disease. It is used, combined 
with adrenalin, in cases having low blood pressure, 
as found in tuberculosis, malnutrition and typhoid 
fever. It is of benefit in relieving tachycardia. 
This product also stimulates digestion and alimen- 
tary peristalsis and is of service in so-called "gen- 
eral rundown condition. " This product is said to be 
of benefit in the treatment of cancerous conditions. 

Principal Indications Pituitary Whole. Lack 
of systemic tone, atony, gastrointestinal atony, low 
blood pressure, malnutrition and hypopituitarism. 
Is a stimulant to heart and blood vessels where they 
lack power and stimulant to the un-striped muscular 
fibers. 

Synergistics. Thyroid, gonads, thymus. 

Dose. One-half to one grain, between meals 
and at bedtime. Tablets of one-half grain. 



ORGANOTHERAPY 47 

PLACENTAL SUBSTANCE 

Source and Parts Used. The placenta of sheep 
and cows is that chiefly used. One part of the 
desiccated parenchyma of the placenta represents 
about six parts of the fresh gland. 

Anatomy and Physiology. The mucous mem- 
brane of the uterus, in the region where the pla- 
centa is attached, becomes hollowed out by sinuses, 
which connect on the one hand with arteries and 
on the other with the veins of the uterus. There 
is no direct communication between the blood ves- 
sels of the mother and that of the fetus, but layers 
of membrane intervene between, making a free 
interchange of matter between them by diffusion 
and osmosis. The normal placenta weighs approx- 
imately four pounds. It has been quite well estab- 
lished that the placenta has an internal hormone 
secretion that favors lactation, uterine involution 
and re-establishes normal conditions after child- 
birth. 

Therapeutic Indication. Extract of the paren- 
chyma of the placenta is used to cause an increase 
in the production of milk. This product has given 
satisfaction in the treatment of fibroma and carci- 
noma of uterus, menorrhagia, dysmenorrhea, en- 
larged and sensitive uterus. It is recommended to 
prevent atrophy of the generative organs after 
ovariotomy, chronic metritis and infections after 
labor. 



48 TREATISE ON 



Synergistics. Mammary gland, pituitary total. 
Dose. Three to nine grains, four times per 
day, between meals. Tablets of three grains. 



PROSTATE GLAND 

Source and Parts Used. These glands are ob- 
tained from cattle and horses. One part of the 
desiccated gland represents about six parts of the 
parenchyma of the prostate gland. 

Anatomy and Physiology. The prostatic 
gland, weighing between four and five drams, is 
situated at the neck of the urinary bladder and 
encloses the commencement of the urethra. It is 
somewhat the shape of a chestnut and is about one 
and one-half inches wide, one and one-quarter 
inches long and one-half inch thick. It is composed 
of compound tubular glands, embedded in muscu- 
lar and connective tissue. 

Therapeutic Indication. This extract has been 
used in prostatic hypertrophy, prostatorrhea, reten- 
tion of urine and neurasthenia of prostatic origin. 
It has been used in the treatment of specific and 
non-specific infection. The extract of the prostate 
gland is not in general use. 

Synergistics. Used in combination with testic- 
ular extracts, lymphatic glands and thyroid. 

Dose. Three to six grains, three times a day, 



ORGANOTHERAPY 49 

between meals. Increased as desired. Tablets of 
three grains. 

SALIVARY GLANDS 

Source and Parts Used. These glands are ob- 
tained from cattle. One part of the desiccated gland 
represents about fifteen to twenty per cent of the 
fresh gland. 

Anatomy and Physiology. There are three 
pairs of glands, namely, the parotid, submaxillary 
and sublingual. These glands are compound 
tubular and made up of lobules with ducts 
that empty into the main duct of the gland. 
The lobules are connected by connective tissue. 
They secrete a mucus of alkaline reaction and 
convert starchy materials into sugar. These glands 
evidently are glands of internal secretion, as evi- 
denced from the effect displayed in cases of orchitis, 
ovaritis and pancreatitis following mumps. 

Therapeutic Indication. Parotid extract has 
been used in the treatment of mumps and pelvic 
disorders of women, as dysmenorrhea, ovaritis and 
ovarian neuralgia, enlarged and tender ovaries, 
chronic endometritis and subinvolution. It has also 
been used successfully in irregular and painful men- 
struation. These products are very little used, as 
there are others that are more efficient in their 
action. 



50 TREATISE ON 



Synergistics. Parotid, ovary and mammary 
substance. 

Dose. Two to eight grains, four times a day, 
between meals. Tablets of two grains. 



SPLEEN 



Source and Parts Used. The spleen is obtained 
from calves, pigs and sheep. The total extract of 
the parenchyma of the spleen is part used. One 
part of the desiccated gland represents about five 
parts of the fresh gland. 

Anatomy and Physiology. The spleen, the 
largest of the so-called vascular glands, weighs 
approximately eight ounces and has no excretory 
duct. It is of a deep reddish brown color and varies 
in shape and also in size, becoming smaller in old 
age. It is situated to the left of the stomach and 
below the diaphragm. The vessels enter and leave 
the gland at the hilus. This organ seems to be 
concerned in the manufacture of the blood corpus- 
cles and is said to act as a filter for the removal, 
from the blood stream, of deteriorated white and 
red corpuscles. It is quite possible that the spleen 
has an influence upon digestion. One feature of the 
chemical composition of the spleen is the presence 
of a special proteid of the nature of alkali-albumin, 
containing organic iron. The salts of the spleen 



ORGANOTHERAPY 51 

consist chiefly of sodium phosphate. The spleen is 
also the source of an active peristaltic hormone. 
This product is apparently only stored in the spleen, 
having been produced in the stomach and duo- 
denum. 

Therapeutic Indication. The total extract of 
the spleen is used in cases of malnutrition, tubercu- 
losis, anemia and chlorosis and in those cases where 
there appears to be a deficiency in the iron, phos- 
phorus and sodium. It is used, also, in tubercu- 
losis of the bone and lymphatic glands, malarial 
toxemia, spleen cirrhosis, inactivity or partial 
paralysis of the intestinal tract and chronic con- 
stipation. 

Counter-indicated. In shock and vasomotor in- 
stability. 

Synergistics. Thyroid, liver, hemoglobin. 

Dose. Five to fifteen grains, three to four 
times a day, after meals. Tablets of five grains. 



STOMACH 



Source and Parts Used. The mucous mem- 
brane of the hog's stomach, that has been excited 
to digestive action, is the part used. The normal 
digestive elements are pepsin and hydrochloric 
acid. Gastrin is obtained by scraping the mucus 
from the pyloric part of the hog's stomach. 



52 TREATISE ON 



Anatomy and Physiology. The stomach is a 
pear-shaped dilation of the alimentary canal, con- 
necting the esophagus and duodenum and lying 
transversely across the upper part of the abdomen 
and below the diaphragm. It consists of four coats, 
serous, muscular, submucous and mucous, weighs 
from four to five ounces and has a capacity of from 
five to eight pints. Normal gastric juice converts 
proteids into peptones. The average amount of 
gastric juice secreted every twenty-four hours is 
from ten to twenty pints. The amount of hydro- 
chloric acid varies from two to two-tenths per cent. 
The chief power of digestion of the gastric juices 
depends on the pepsin and hydrochloric acid. The 
general effect of stomach digestion is the conver- 
sion of food into chyme. 

Therapeutic Indication. Principal indications 
are gastric indigestion, dyspepsia and acute con- 
ditions, where there is a disturbance of gastric 
digestion, requiring the assistance of digestive 
ferments. These products are also frequently given 
with indicated medication in gastric conditions. 

Synergistics. Hydrochloric acid, papain and 
stomachic. 

Dose. Two to five grains after meals. Best 
given in solution with hydrochloric acid. 



ORGANOTHERAPY 53 

TESTICLES 

Source and Parts Used. Testicles of rams and 
bulls are most suitable for producing the active 
therapeutic properties. One part of the desiccated 
substance represents about seven of the fresh gland, 
depending on the age of the animal. 

Anatomy and Physiology. The gland weighs 
from six to eight drachms. Orchic extract, pre- 
pared from this gland, contains at least four active 
principles — viz. phosphorized albumin, lecithin 
(phosphorized fats), spermin and nuclein. The 
first two are of value as nerve constructives, the 
third is said to increase the oxygen-carrying power 
of the corpuscles and the fourth possesses bacteri- 
cidal properties. The chief chemical elements are 
associated with nutrition, oxidation and cell activity 
in general. The cells of Leydig are supposed to be 
the seat of the formation of the internal secretion 
of the testes. At puberty there is a great develop- 
ment of these cells and a marked atrophy of same 
cells at old age. 

Therapeutic Indication. Principal indications 
of orchic substance are infantilism, congenital mal- 
formation, sterility, premature senility, impotence 
and testicular insufficiency and debility, melan- 
cholia, neurasthenia, defective oxidation, defective 
growth and mentality. Good results have been 
obtained by the use of this product in amenorrhea 



54 TREATISE ON 



and treatment of the menopause. This product 
has been used with benefit in diabetes and tubercu- 
losis. 

Synergistics. Small doses of thyroid, prostate, 
lymphatic glands, adrenal glands and the usual drug 
medication. 

Dose. Two to ten grains, four times per day. 
Dose to be increased, as required, over an extended 
period of time. Tablets of two grains. 



THYMUS GLAND 

Source and Parts Used. The thymus gland is 
obtained from cattle and sheep, preferably the 
fetal animal. The total gland is used. One part 
of the desiccated gland represents about six parts 
of the fresh gland. 

Anatomy and Physiology. This gland, consist- 
ing of two lobes, is situated in front of the trachea 
and over the top of the sternum and weighs, 
normally, about 75 grains. Development of this 
gland takes place in the fetus and early childhood 
and reaches its height of development about the 
age of two years. It then gradually diminishes in 
size until, in adult life, but a small vestige remains. 
The thymus gland has a decided influence upon the 
metabolism of mineral salts, especially lime, and 



ORGANOTHERAPY 55 

also regulates the phosphorus. It appears, also, 
to regulate the growth and activities of the sexual 
organs in childhood and seems to have an influence 
upon the ossification of the bones. 

Therapeutic Indication. The extract of this 
gland has been used in a variety of diseases, as 
cretinism, deficient development, exophthalmic 
goiter, chlorosis, rickets, delayed union of fractures, 
arthritis, malnutrition and deficient growth. It has 
also proven of benefit in anemia, pernicious anemia, 
lymphatic disorders and Grave's disease. The 
thymus extract has exceeded all other therapeutic 
preparations. It is especially rich in nuclein, which 
possesses a large proportion of organic phosphorus. 

Nuclein is a proteid substance possessing phos- 
phorus in the form of Nucleinic Acid. Nucleins, 
the chief chemical constituents of cell nuclei, are 
found in both animal and vegetable tissues. 
Wherever there is a nucleus there is found nuclein. 
Nuclein is generally insoluble in dilute acids, but 
soluble in dilute alkalies and resists peptic diges- 
tion. It has four principal functions, to serve as a 
natural antiseptic, to destroy toxic products which 
accumulate through faulty elimination, to act as a 
natural bactericide and to resist microbe invasion. 
This product is obtained from yeast cells and from 
a number of the endocrine glands and animal 
tissues, as the thymus, thyroid, liver and spleen. The 
giving of nuclein causes no functional disturbance, 



56 TREATISE ON 



but does cause a marked increase of the leucocytes 
in both healthy and unhealthy subjects. Nuclein 
has been therapeutically employed in the treatment 
of infectious diseases such as pneumonia, typhoid 
fever, tuberculosis, rickets, erysipelas and kindred 
troubles. This product has been found of benefit, 
also, in the treatment of dementia perecox and gen- 
eral paresis. Nuclein medication is prompt and 
permanent. 

Dose. One-half to two grains, to be increased, 
if required. 

Principal Indications. Delayed development in 
children and cases where there is disturbance of 
the mineral metabolism, malnutrition, exophthal- 
mic goiter, acute and chronic infectious diseases, 
especially the chronic of an asthenic type, as tuber- 
culosis and anemia. 

Counter-indicated. Thymus product should be 
given with care in uric acid diathesis, rheumatic 
and gouty conditions. 

Synergistics. Calcium salts in tubercular or 
lymphatic diseases. Anterior pituitary gland in 
Grave's disease, thyroid and gonads. 

Dose. Three to six grains of desiccated gland 
four to five times per day, about one hour after 
meals. To be increased as indicated. Tablets of 
three grains. 



ORGANOTHERAPY 57 

THYROID GLAND 

Source and Parts Used. The animals from 
which the thyroid glands are obtained are, princi- 
pally, lambs and sheep. The glands, freed of their 
connective tissue and all fat, are desiccated, pow- 
dered and standardized to contain approximately 
.2 per cent of actual iodine. One part of the dried 
substance represents about six parts of the fresh 
gland. 

Anatomy and Physiology. The thyroid gland, 
weighing from one to two ounces, is the most im- 
portant of the ductless glands and its therapeutic 
efficiency has been thoroughly proven. It is 
situated in the neck at the upper portion and in 
front of the trachea and consists of two lobes, 
situated one on each side of the trachea and con- 
nected by a band called the isthmus. The gland, 
which is surrounded by a capsule, is composed of 
vesicles lined with cylindrical cells, embedded in 
fat and connective tissue. The vesicles contain a 
viscid yellowish fluid, the chemical constituents of 
thyroid extract, and include iodothyrin, which is 
its active principle. Iodothyrin contains organic 
iodine, nitrogen, sulphur and phosphorus. This 
gland is larger in the female than in the male. It 
is known to become enlarged during excitement or 
emotional strain and is one of the chief detoxicating 
agents of the body. Upon removal of the thyroid 



58 TREATISE ON 



tetany sets in and the animal dies of cachexia. It 
is found that the thyroid gland is concerned with 
calcium metabolism. With a lack of thyroid secre- 
tion, there is a lack of the calcium. With excess 
thyroid secretion, there is an increase of the cal- 
cium leaving the body. Human beings who have 
a deficient thyroid secretion are susceptible to cold 
and suffer increased discomfort during the winter. 
The opposite is true of individuals with the hyper- 
secretion of the thyroid, as in Grave's disease, 
where they do not suffer inconvenience from cold 
weather, but feel the heat of summer very per- 
ceptibly. It is a well-known fact that these indi- 
viduals suffer very much from nervousness and 
restlessness and are subject to rapid loss of flesh, 
which in some cases reaches actual emaciation. 

Therapeutic Indication. The history of thyroid 
therapy is fairly well established, as it has been 
successfully used in the treatment of parenchym- 
atous goiter showing deficient thyroid secretion 
of the proper hormones. In congenital absence or 
pathological destruction of the thyroid gland, there 
are defective secretive conditions. These condi- 
tions are very pronounced in myxedema, cretinism, 
infantilism, certain mental disorders and forms of 
insanity, obesity and anemia. This product is rec- 
ommended in certain symptoms of insanity, includ- 
ing hysteria, melancholia, dementia and other 
peculiarities associated with thyroid disorders that 



ORGANOTHERAPY 59 

very often accompany the menopause. This 
product is often found of benefit in the treat- 
ment of rheumatic conditions, arthritis, migraine, 
arterio-sclerosis, defective oxidation, malnutrition 
and defective circulatory conditions. Thyroid 
extract has been used with success in irregular 
hemorrhages of the menopause, uterine fibroids, 
rickets, progressive muscular atrophy and in- 
somnia. This product is recommended in the 
treatment of dysmenorrhea, amenorrhea and 
chlorosis. Acromegaly has yielded to the com- 
bined treatment of thyroid extract and pituitary 
gland substance. Tetany, torticollis and epilepsy 
are found to be benefited by this combination. 

Principal Indication. Temperature, tendency 
to subnormal, 97 to 98 degrees Fahrenheit, patient 
feels cold. Headaches, usually frontal or occipital, 
tendency to rhinitis. Teeth easily become carious, 
soft, subject to pyorrhea. Tonsils usually enlarged 
and subject to slight and severe attacks. Patient sub- 
ject to colds, in winter to bronchitis. Poor circula- 
tion, pulse rather slow, about 60 to 65. Patient's 
appetite not large, many times craves sweets, sub- 
ject to gaseous eructations after meals. There is 
a relaxation of ligaments, crackling noise on motion 
of small joints. Sudden increase of weight without 
obvious reasons, one might suspect thyroid dis- 
turbance, showing poor oxidation. Skin is dry, 
rough, eczematous condition, sometimes intense 



60 TREATISE ON 



itching. Hair usually coarse and dry, lacks luster, 
tendency to come out, scarcity of hair in eyebrows. 
Constipation is nearly always present. These sub- 
jects are prone to fatigue and may present the 
appearance of senility. Small doses of thyroid, 
given at intervals in elderly persons, may be found 
of benefit to help keep the arteries soft in those 
cases where poor oxidation is in evidence. 

Thyroid product is found of benefit in hypothy- 
roidism, myxedema, cretinism, obesity, arterio- 
sclerosis with low blood pressure, malnutrition, 
rheumatism and arthritis. 

You will note hyperthyroidism presents the 
opposite line of symptoms, in which case thyroid 
extract should not be given. 

Counter-indicated. Thyroid extract is counter- 
indicated in the majority of cases involving hyper- 
thyroidism, Grave's disease, excessive circulatory 
disturbance, palpitation and shortness of breath. 
The symptoms underlying these troubles are 
caused by an excess of thyroid secretion and the 
giving of thyroid extract would increase the 
severity of the trouble. 

Synergistics. Thyroid extract in small doses 
has proven to be of much therapeutic value in com- 
bination with other glandular extracts. Iodides 
frequently enhance its therapeutic efficiency. 

Dose. It has been proven that this product has 
been given in too large doses. Overdoses will be 



ORGANOTHERAPY 61 

followed by more or less irritability of the nervous 
and circulatory system producing tachycardia, 
insomnia, headache, dizziness and pains in the back 
and limbs. When these symptoms occur this pro- 
duct should be withdrawn. One quarter of a grain 
is quite sufficient to start with. Dose to be in- 
creased, if conditions permit and it is required. 
Tablets of one-fourth grain. 



TONSIL 



Source and Parts Used. Tonsils of calves and 
other young animals are used. Total extract of the 
gland. No preparation of this product is on the 
market. 

Anatomy and Physiology. The tonsils, two in 
number, consisting of glandular tissue, are situated 
between the anterior and posterior arches of the 
soft palate. Each has from fifteen to twenty open- 
ings. The tonsil is bound by a fibrous capsule. 
There is a mucous secretion from the tonsil which 
serves to lubricate and moisten the throat. 

Therapeutic Indication. It has been said that 
the tonsils are the most active of the organic ex- 
tracts. The desiccated powder of this gland is said 
to increase both red and white corpuscles and 
reduce blood pressure. Said to be of service in 
treatment of diabetes and anemia. The extract 



62 TREATISE ON 



of this gland has not been demonstrated, as to its 
true clinical therapeutics. 

Dose. This depends upon age of animal. 
Clinical work has not as yet established the dose 
for this extract. 



UTERINE EXTRACT 

An extract made from the substance of the 
uterus has been employed in disorders and condi- 
tions which follow as a consequence of the re- 
moval of the uterus and its appendages. There 
is not sufficient data to enable any conclusion to 
be formed as to the efficiency of this extract, there- 
fore more knowledge must be acquired before we 
shall be able to give the true therapeutics. 



ORGANOTHERAPY 63 

ADRENAL OVARIAN PANCREAS 
COMPOUND 

Adrenal (Total) gr. J4 

Pituitary (Total) gr. y 2 

Ovarian Substance gr. \y 2 

Pancreas (Total) gr. 3 

Indicated. Nervousness and irritable condi- 
tions due to hypersecretion of the thyroid. Dis- 
turbed and irritable condition of the circulatory 
organs. Irregular heart, rapid and weak pulse. 
This product will be found of benefit in overcoming 
disturbed conditions due to ovarian troubles. It 
acts as a sedative to the sympathetic system. 

Dose. One tablet four times a day, one to two 
hours before meals. Would suggest the giving of 
spermin extract, from y 2 to 1 grain, in combination 
with this formula for men, when indicated as 
stated above. 



ADRENAL PITUITARY COMPOUND 

Adrenal (Total) gr. */ 2 

Pituitary (Anterior Lobe) . . . .gr. 1^2 
Sodium, Calcium, Potassium 

Compound gr. 3 

Indicated. Bronchial asthma and spasmodic 
conditions of the pulmonary tract. In conjunction 



64 TREATISE ON 



with the giving of the above product antispas- 
modics, no doubt, will be in order for immediate 
relief, afterward continuing the above formula for 
some time. 

Dose. One tablet four to five times a day, as 
indicated. 



ADRENAL AND SECRETIN COMPOUND 

Adrenal Substance (Total) . . . .gr. J4 

Secretin (Duodenal) gr. 2 

Bile Salts gr. 2 

Sodium, Calcium, Potassium 

Compound q. s. gr. 6 

Indicated. Chronic indigestion, associated with 
pancreatic and biliary inactivity, constipation, clay- 
colored stools, hypochlorhydria, fermentation of 
food in intestinal tract and toxemia. This combina- 
tion stimulates the digestive secretions and assists 
assimilation. 

Dose. One to two tablets two hours after eat- 
ing, to be increased as conditions require and to be 
given, in chronic cases, over an extended period. 



ORGANOTHERAPY 65 

ADRENAL THYROID SPERMIN 
COMPOUND 

Adrenal Substance (Total) gr. J4 

Thyroid Gland gr. 1/10 

Spermin Extract gr. 1 

Lecithin gr. 1 

Sodium, Calcium, Potassium 

Compound q. s. gr. 5 

Indicated. In a general run down condition, as 
follows acute infectious diseases, chronic asthenic 
conditions, fatigue, low blood pressure and lowered 
vitality. This product should be given over an 
extended period. 

Dose. One tablet four times a day. Increased 
blood pressure is a guide to the giving of this tablet. 



ADRENAL THYROID SPLEEN COMPOUND 

Adrenal Gland (Total) gr. J4 

Spermin gr. 2 

Thyroid gr. 1/20 

Spleen Substance gr. 3 

Indicated. In tuberculosis and as a tonic where 
nutrition has been greatly interfered with, as evi- 
denced by loss of flesh and muscular energy. This 
condition is found in cases of tuberculosis, malaria 
and other wasting diseases. 

Dose. One tablet after meals and at bedtime. 

5 



m TREATISE ON 



HEMOGLOBIN, NUCLEIN COMPOUND 

Hemoglobin gr. 3 J^ 

Spleen (Total) gr. \y 2 

Nuclein gr. y 2 

Sodium, Calcium, Potassium 

Compound gr. y 2 

Indicated. Anemia, pernicious anemia, cachexia 
and in other conditions, where a ferruginous tonic 
is indicated. Hemoglobin (organic iron) is the 
most easily assimilable of any iron combination 
and is not constipating. 

Dose. One tablet after meals and at bedtime. 
More often if required. 



HEPATIC AND BILE SALTS COMPOUND 

Hepatic Substance gr. 2y 2 

Bile Salts gr. 3 J4 

Indicated. Chronic hepatic troubles, as cirrho- 
sis and hypertrophy. Stimulates flow of bile, 
promotes intestinal digestion, relieves intestinal 
fermentation and constipation. This combination 
will be found of benefit in functional hepatic 
troubles and gall stones. 

Dose. One tablet before meals and at bedtime. 
If constipation is pronounced, increasing doses 
should be given, until results are obtained. Then 
lessen doses and give over an extended period. 



ORGANOTHERAPY 67 

HEPATIC, BILE AND PANCREATIN 
COMPOUND 

Hepatic Substance gr. 2^4 

Bile Salts gr. 2 

Pancreatin gr. \y 2 

Indicated. Intestinal indigestion with liver in- 
activity, toxemia and alimentary stasis. 

Dose. One to two tablets two hours after 
meals, as required. 



HEPATIC, SPLEEN AND ADRENAL 
COMPOUND 

Hepatic Parenchyma gr. 2 

Spleen Substance gr. 2 

Bile Salts gr. y A 



Adrenal Substance (Total) . . . .gr. *4 

Indicated. Hepatic and intestinal inactivity, 
which in the majority of cases depend upon the 
sluggish condition of the liver and malnutrition fol- 
lowing the toxic conditions from liver inactivity. 

Dose. One tablet four times a day, as required, 
and over an extended period in chronic conditions. 



68 TREATISE ON 



KIDNEY, PANCREAS COMPOUND 

Kidney Desiccated 

(Nephritin) gr. 3 

Pancreas (Total) . . gr. 2 

Indicated. In deficient renal activity, acute or 
chronic nephritis (Bright's disease), uremia, 
eclampsia and albuminuria of pregnancy. By the 
giving of this product in edema and ascites due 
to, or partly due to, nephritis, there should be a 
reduction of these conditions, as I believe this pro- 
duct has diuretic properties, owing to its action on 
the tubules of the kidney. There is also a lessening 
of the albumin passing and an increase of chlorides. 
Kidney substance given in these troubles lowers the 
nitrogen — that has been retained in the blood — and 
will be found of benefit in rheumatic conditions, due 
to this cause. Pancreas tends to neutralize adrenal 
irritability and will be found of benefit in this 
product. 

Dose. One tablet to be given four times a day, 
between meals. Increased as required. Strict at- 
tention should be given to the diet, bowels and 
skin. Hygiene also must be regarded. Proper rest 
and other conditions, as high blood pressure and 
arterio-sclerosis, must be considered by the physi- 
cian. Treatment with this product should be given 
as soon as nephritis is discerned. Would suggest 
the giving of thyroid extracts, grs. }i to %, in con- 



ORGANOTHERAPY 69 

junction with this formula, where high blood 
pressure or hyperthyroidism is not a complication. 



LECITHIN, NUCLEIN, HEMOGLOBIN 
COMPOUND 

Lecithin (90 to 95%) gr. 2 

Nuclein gr. 1 

Hemoglobin gr. 2 

Sodium, Calcium, Potassium 

Compound gr. 2 

Indicated. As a reconstructive tonic to the 
nervous system, especially in chronic nervous dis- 
orders and malnutrition. The organic phosphorus 
and iron as contained in this formula are easily 
assimilable. 

Dose. One tablet four times a day, after meals. 



LYMPHATIC, SPLEEN AND THYROID 
COMPOUND 

Lymphatic Glands gr. 2 

Spleen Substance gr. 2 

Thyroid Gland gr. 1/20 

Sodium, Calcium, Potassium 

Compound q. s. gr. 6 

Indicated. Lymphatic enlargement, lack of 
thyroid secretion (hypothyroidism), anemia in 



70 TREATISE ON 



children and adults and in cases having a tendency 
to hemorrhage. 

Dose. One to two tablets three to four times 
a day, with food. 



MAMMARY AND PITUITARY COMPOUND 

Mammary Substance gr. 3 

Pituitary (Total) gr. 1/3 

Sodium, Calcium, Potassium 

Compound q. s. gr. 5 

Indicated. In functional or organic menstrual 
disorders, menorrhagia, metrorrhagia, excessive or 
prolonged menstrual flow, excessive climacteric 
hemorrhages and uterine hemorrhages due to 
fibroid or cancerous condition. 

Dose. One tablet every three to four hours. 
Ergotin should be given with this formula, as in- 
dicated, and discontinued when not required, still 
continuing the above formula, as is needed. 



MAMMARY, PITUITARY AND PLACENTAL 
COMPOUND 

Mammary Substance gr. \ l / 2 

Pituitary (Total) gr. y 2 

Placenta Desiccated gr. 2 

Sodium, Calcium, Potassium 

Compound q. s. gr. 6 



ORGANOTHERAPY 71 

Indicated. Galactagogue, mammary stimulant, 
increasing the supply and nourishing quality of 
milk in nursing mothers. Favors uterine in- 
volution. 

Dose. One to two tablets after meals and at 
bedtime, to be increased as required. 



NUCLEIN, SPERMIN, HEMOGLOBIN 
COMPOUND 



Nuclein gr. 



Lecithin (95%) gr. 1 

Spermin gr. 1 

Hemoglobin gr. 2^4 

Indicated. Organic iron and phosphorus in 
combination that is easily assimilated and does not 
constipate the patient. This product will be found 
of benefit in cases of anemia, malnutrition and 
where there is a need to increase both the white 
and red blood corpuscles, giving the patient a bet- 
ter stability of health. 

Dose. One to two tablets one hour after meals 
and at bedtime, as indicated. 



72 TREATISE ON 



PANCREAS, THYROID, GONADS 
COMPOUND 

Pancreas (Total) gr. 2 

Thyroid Gland gr. 1/16 

Gonads A. A. gr. \y 2 

Sodium, Calcium, Potassium 

Compound , q. s. gr. 5 

Indicated. In high blood pressure of male or 
female, the cause not being entirely due to renal 
or circulatory troubles. There is a stimulating ef- 
fect of oxidation and cell activity. 

Dose. One tablet after meals and at bedtime. 



PANCREAS, TRYPSIN COMPOUND 
(DIABETES) 

Pancreas gr. 2y 2 

Trypsin gr. 2 

Amylopsin gr. J / 2 

Indicated. In defective carbohydrate metabo- 
lism, glycosuria, diabetes mellitus of pancreas 
origin. Medicinal products may be given as in- 
dicated. Care should be used in giving prepara- 
tions of arsenic, where the condition is complicated 
with albuminuria. However, these products will 
be found of much value, when indicated. Before 
treatment is begun the system must be thoroughly 
alkalized to obtain results, as the acid conditions, 



ORGANOTHERAPY 73 

that are found in diabetic cases, must be overcome. 
Would recommend the giving of tablets, sodium, 
lime and potassium compound, one to two tablets 
with water, one hour before meals and at bedtime. 
Should constipation become annoying, use saline 
laxatives. When the urine and feces show they 
are alkaline the above treatment should be begun 
and the alkalies should be given along gradually 
to keep the acids from predominating. Have the 
patient follow the strict diet and hygiene, as this 
must be done to obtain results. It has been stated 
that the dropping of a solution of adrenalin in the 
eye of an animal from which the pancreas has been 
removed causes dilation of the pupil, which action 
does not occur in a normal animal. This test has 
been used to diagnose pancreatic diabetes from 
liver diabetes. 

Dose. Two to six tablets, two hours after meals 
and at bedtime. This treatment is to be given over 
an extended period. 



PARATHYROID, SPERMIN, BILE 
COMPOUND 

Parathyroid Gland gr. 1/20 

Spermin Extract gr. 1 

Bile Salts gr. 2 

Sodium, Calcium, Potassium 

Compound q. s. gr. 5 



74 TREATISE ON 



Indicated. When parathyroid glands require 
stimulation and an added muscular tone, as in 
paralysis, chorea, paralysis agitans, senility and 
deficient oxidation. 

Dose. One tablet four times a day. Increase 
dose, as required. 



PITUITARY, ADRENAL, LYMPHATIC 
COMPOUND 

Pituitary (Anterior Lobe) . . . .gr. Y\ 

Adrenal (Cortex) . . . . gr. }i 

Lymphatic Glands gr. 1 

Lecithin gr. 1 

Spermin gr. 1 

Thyroid gr. 1/10 

Indicated. Lowered vitality of the functional 
organs, senility, neurasthenia. 

Dose. One tablet three to four times a day. 



PITUITARY ANTERIOR AND TOTAL 
COMPOUND 

Pituitary (Anterior Lobe) gr. 1 

Pituitary (Total) gr. 1 

Sodium, Calcium, Potassium 

Compound gr. 3 



ORGANOTHERAPY 



Indicated. Lack of development of the gonads, 
infantilism and cases requiring increased cellular 
activity. Stimulates metabolism. 

Dose. One tablet four times a day. 



PITUITARY THYMUS, THYROID 
COMPOUND 

Pituitary (Anterior Lobe) . . . .gr. 1 

Thymus Gland gr. 1 

Thyroid Gland gr. 1/16 

Sodium, Calcium, Potassium 

Compound q. s. gr. 6 

Indicated. In children with defective mentality 
and growth, backward children, those subject to 
chorea, epilepsy, cretinism, anemia, lymphatic dis- 
orders and blood dyscrasia. 

Dose, One tablet two to three times a day, as 
indicated, for a few months. 



PROSTATE, SPERMIN, LYMPHATIC 
COMPOUND 

Prostate . gr. \y 2 



Spermin gr. \y 2 

Lymphatic gr. \y 2 

Nuclein gr. % 

Sodium, Calcium, Potassium 

Compound q. s. gr. 6 



TREATISE ON 



Indicated. Prostatic diseases, as enlarged 
prostate, prostatic irritation, neurasthenic condi- 
tions depending on prostatic troubles, lack of 
gonad activity, senility, defective nutrition, im- 
potency, neurasthenic conditions and mental 
diseases. This product will be found of benefit 
in the treatment of women who are of a neuras- 
thenic tendency. 

Dose. One tablet three to four times a day. 
This product should be given for some time. In- 
dicated medication may be used in conjunction, if 
desired. 



SODIUM, CALCIUM, POTASSIUM COM- 
POUND (ALKALINE TABLET) 

Sodium Phosphate pts. 2 

Calcium Phosphate pts. 4 

Calcium Glycerophosphate . . . .pts. 2 

Magnesium Phosphate pts. 1 

Potassium Bicarbonate pts. 16 

Sodium Bicarbonate pts. 25 

Indicated. As an antacid which aids in neu- 
tralizing the excessive tendency of the body to acid, 
(acidosis), which tendency is most common in 
cases associated with endocrine insufficiencies. This 
product is useful in toxic conditions that are due to 



ORGANOTHERAPY 77 

alkaline deficiency. There should be a thorough 
alkaline condition of the body established, in con- 
junction with glandular extract treatment, as this 
formula represents approximately, with the excep- 
tion of sodium chloride, the proportions of mineral 
salts present in the blood under normal conditions. 
It is therefore indicated to overcome this acid 
condition that has been due to poor oxidation and 
to re-establish these alkaline mineral requirements 
of the blood and tissues. Acids are the weapons 
of death, while the alkalies are the foes of death. 

Dose. One to two tablets dissolved in plenty 
of water, one to two hours before meals and at bed- 
time. This treatment should be continued for a 
few weeks, to overcome the acid condition. 



SPERMIN, THYROID COMPOUND 

Spermin . . . . . . . gr. 2y 2 

Thyroid gr. 1/20 

Sodium, Calcium, Potassium 

Compound q. s. gr. 5 

Indicated. Impotency, enlarged prostate, sen- 
ility, a general asthenic condition of the gonads. 

Dose. One tablet four times a day, to be in- 
creased if required and given over an extended 
period. 



TREATISE ON 



THYMUS, LYMPHATIC, PITUITARY 
COMPOUND 

Thymus Gland gr. 1 

Lymphatic Glands gr. 2y 2 

Pituitary (Anterior Lobe) . . . .gr. y 2 
Sodium, Calcium, Potassium 

Compound q. s. gr. 6 

Indicated. In slow development of children, 
especially those troubled with recurrent adenoids 
and hypertrophied tonsils. This product assists in 
reconstruction by supplying the needed hormones 
of the endocrine glands. Alterative. 

Dose. One tablet four times a day, as required. 



THYMUS, THYROID, ADRENAL 
COMPOUND 

Thymus Gland gr. 1 

Thyroid Gland gr. 1/10 

Adrenal Gland (Total) gr. J4 

Pituitary Gland (Anterior 

Lobe) gr. y 2 

Prostate Gland gr. \y 2 

Orchic Substance gr. 2 

Sodium, Calcium, Potassium 

Compound q. s. gr. 6 T / 2 

Indicated. Infantilism and endocrinous dis- 
orders of the adult, treatment of children showing 



ORGANOTHERAPY 79 

backward development, asthenia, hypochondriasis, 
melancholia, functional and endocrine impotency, 
sexual neurasthenia and sterility. 

Dose. One tablet four times a day, to be in- 
creased, as required and given over an extended 
period. Indicated medications may be given, as 
indications present themselves. 



THYMUS, THYROID, PITUITARY 
COMPOUND 

Thymus Gland gr. 3 

Thyroid Desiccated gr. j4 

Pituitary (Total) gr. 1/20 

Ovary gr. 1 

Testes gr. 1 

Sodium, Calcium, Potassium 

Compound q. s. gr. 6 

Indicated. In chronic rheumatism, arthritis 
deformans and pains in joints. This product will be 
found of service in myalgia, when there is poor 
metabolism and elimination. 

Dose. One tablet four times a day, to be given 
for several weeks. Then treatment discontinued 
for a time, to be begun again and given for some 
time. Diet and hygiene must be observed. When 
cases are complicated with low blood pressure, the 
giving of the adrenal gland with the above formula 
in doses of }£ to % grain will be of benefit. 



TREATISE ON 



THYROID AND GONADS COMPOUND 

Thyroid Desiccated gr. y$ 

Ovary gr. 1 

Testes gr, 1 

Sodium, Calcium, Potassium 

Compound q. s. gr. 5 

Indicated. Neurasthenia, premature debility of 
old age and asthenic conditions, menstrual disor- 
ders and climacteric disturbances, suboxidation, in- 
somnia and the headaches that are associated with 
high blood pressure. Debilitated conditions, as 
noted when patient lacks vigor, has a general run- 
down condition and chronic cardiac disturbances, 
with high blood pressure. 

Dose. One to two tablets, three to four times 
a day, one hour before meals, over an extended 
period. 



THYROID, NUCLEIN COMPOUND 

Thyroid Gland gr. % 

Nuclein gr. J4 

Ferri Iodide Sacch gr. j4 

Sodium, Calcium, Potassium 

Compound gr. 5 

Indicated. Goiter or enlargement of the thyroid 
gland, due to a lack of thyroid secretion, as is noted 



ORGANOTHERAPY 81 

in young girls at the age of puberty and women 
during ovarian changes. These cases rarely pre- 
sent the symptoms of anemia or malnutrition. 

Dose. One tablet, three to four times a day, be- 
tween meals. 



THYROID, OVARIAN AND MAMMARY 
COMPOUND 

Thyroid (Total) gr. 1/10 

Ovarian Substance gr. 1 

Mammary Substance gr. 2j/£ 

Sodium, Calcium, Potassium 

Compound q. s. gr. 6 

Indicated. Too frequent and prolonged men- 
struation, dysmenorrhea, ovarian and pelvic con- 
gestion, tender and irritable ovaries, menorrhagia, 
metrorrhagia. Will be found of service at the cli- 
macteric. 

Dose. One tablet, three to four times a day, 
beginning a week before menstruation and con- 
tinuing during the flow. 



82 TREATISE ON 



THYROID, PITUITARY AND GONADS 
COMPOUND 

Thyroid Desiccated gr. y& 

Pituitary (Total Gland) gr. 1/20 

Ovary gr. 1 

Testes gr. 1 

Sodium, Calcium, Potassium 

Compound q. s. gr. 5 

Indicated. Neurasthenia, premature debility of 
old age and asthenic conditions, menstrual disor- 
ders and climacteric disturbances, suboxidation, in- 
somnia and the headaches that are associated with 
low blood pressure. Debilitated conditions, as 
noted when patient lacks vigor, has a general run- 
down condition and chronic cardiac disturbances, 
with low blood pressure. 

Dose. One to two tablets, three to four times 
a day, one hour before meals, over an extended 
period. Suggest the giving of adrenal gland, grain 
Yz to J4, when the patient has low blood pressure. 



ORGANOTHERAPY 83 

THYROID, PITUITARY, PANCREAS COM- 
POUND 

Desiccated Thyroid (Whole 

Body) gr. 1/25 

Pituitary (Whole Body) gr. 1/50 

Spleen Substance gr. 1 

Pancreas gr. \y 2 

Hepatic gr. 1 

Sodium, Calcium, Potassium 

Compound q. s. gr. 5 

Indicated. To assist metabolism in wasting dis- 
eases and conditions of malnutrition. This com- 
bination will be found of benefit in cases where it 
is found necessary to increase weight, as in tuber- 
culosis and lowered vitality, as it tends to raise 
body resistance to infection and aids normal diges- 
tion. The giving of this combination can be rec- 
ommended for undernourished children. Would 
recommend the indicated medicinal tonics, where 
required. 

Dose. Two to four tablets, before eating and 
at bedtime, as required. 



84 TREATISE ON 



THYROID, PLACENTA COMPOUND 

Thyroid Gland gr. 1/20 

Placenta (Desiccated) gr. 4 

Sodium, Calcium, Potassium 

Compound q. s. gr. 6 

Indicated. In vomiting and nausea of preg- 
nancy. 

Dose. One to two tablets, taken four to five 
times a day, with as hot water as can be taken. 



THYROID, SODIUM, CALCIUM, POTAS- 
SIUM COMPOUND 

Thyroid gr. y$ 

Sodium, Calcium, Potassium 

Compound q. s. gr. 5 

Thyroid . gr. % 

Sodium, Calcium, Potassium 

Compound q. s. gr. 5 

Thyroid gr. y 2 

Sodium, Calcium, Potassium 

Compound q. s. gr. 5 

Indicated. Thyroid insufficiency, hypothyroid- 
ism, myxedema and cretinism. These patients 
generally run a subnormal temperature, have poor 
circulation and slow pulse. The skin is dry and 
rough, and may be eczematous, the nails are brittle 



ORGANOTHERAPY 85 

and the teeth soft and subject to decay and the 
hair turns prematurely gray. These patients are 
nearly always constipated, require abundance of 
sleep, are inclined to obesity and very prone to 
fatigue and circulatory disturbances. They are 
subject to migraine, asthmatic attacks, chronic 
rheumatism, gout and mental symptoms. Thyroid 
extract is given with the view of increasing the 
cell chemistry and replacing the depleted alkaline 
salts. 

Dose. The patient should always be started 
with a small dose, to be increased as conditions 
warrant and can be tolerated. One tablet before 
meals and at bedtime. 



TRYPSIN, PANCREATIN AND PAPAIN 
COMPOUND 

Trypsin gr. y 2 

Pancreatin gr. 2 

Papain gr. 1 

Berberine Muriate gr. 1/10 

Jamaica Ginger gr. 1 

Indicated. Gastro-intestinal indigestion, flatu- 
lence and fermentation. Aids digestion of proteid 
and starch. 

Dose. One to two tablets, one hour and a half 
after meals. 



INDEX 

Adrenal Glands 15 

Adrenal Cortex 16 

Adrenal Medulla 16 

Adrenal Total 16 

Adrenal Ovarian Pancreas Compound 63 

Adrenal Pituitary Compound 63 

Adrenal and Secretin Compound 64 

Adrenal Thyroid Spermin Compound 65 

Adrenal Thyroid Spleen Compound 65 

Antithyroid »*Serum 19 

Appendix 18 

Bile 27 

Blood 19 

Bone 21 

Bone Medulla 22 

Brain and Spinal Cord 22 

Carotid Gland 24 

Corpus Luteum 36 

Duodenum (Secretin) 25 

Hemoglobin 19 

Hemoglobin Nuclein Compound 66 

Hepatic and Bile Salts Compound 66 

Hepatic Bile and Pancreatin Compound 67 

Hepatic Spleen and Adrenal Compound 67 

Kidneys (Nephritin) 26 

Kidney Pancreas Compound 68 

Lecithin Nuclein Hemoglobin Compound 69 

Leucocyte Extract 19 

87 



88 INDEX 



Liver and Bile 27 

Lungs 30 

Lymphatic Glands 31 

Lymphatic Spleen and Thyroid Compound 69 

Mammary Glands 33 

Mammary and Pituitary Compound 70 

Mammary Pituitary and Placental Compound....... 70 

Melanine 34 

Nephritin 26 

Normal Serum 19 

Nuclein Spermin Hemoglobin Compound 71 

Ovaries 34 

Pancreas 39 

Pancreas Thyroid Gonads Compound 72 

Pancreas Trypsin Compound (Diabetes) 72 

Parathyroid Gland 41 

Parathyroid Spermin Bile Compound 73 

Pineal Gland 42 

Pituitary Body 43 

Pituitary Body Anterior Lobe. 45 

Pituitary Body Posterior Lobe 44 

Pituitary Body Whole Gland 46 

Pituitary Adrenal Lymphatic Compound 74 

Pituitary Anterior and Total Compound 74 

Pituitary Thymus Thyroid Compound 75 

Placental Substance 47 

Prostate Gland 48 

Prostate Spermin Lymphatic Compound 75 

Salivary Glands 49 

Secretin 25 

Sodium Calcium Potassium Compound (Acidosis) 76 

Spermin Thyroid Compound 77 



INDEX 89 



Spinal Cord 22 

Spleen 50 

Stomach 51 

Testicles 53 

Thymus Gland 54 

Thymus Lymphatic Pituitary Compound 78 

Thymus Thyroid Adrenal Compound 78 

Thymus Thyroid Pituitary Compound 79 

Thyroid Gland 57 

Thyroid and Gonads Compound 80 

Thyroid Nuclein Compound 80 

Thyroid Ovarian and Mammary Compound 81 

Thyroid Pituitary and Gonads Compound 82 

Thyroid Pituitary Pancreas Compound 83 

Thyroid Placenta Compound 84 

Thyroid Sodium Calcium Potassium Compound 84 

Tonsil 61 

Trypsin Pancreatin and Papain Compound 85 

Uterine Extract 62 



